ABSTRACT
To study the effect of supplementation of Lactobacillus acidophilus on lipid profile in hypercholesterolemia individuals. Thirty hypercholesterolemia subjects (15 men and 15 women) with ages ranging between 42-53 years old were included in the study and the intervention was performed for a period of 60 days. During the intervention all 30 subjects were divided into three groups comprising of 10 individuals in each group. Group A and B were given 10 × 106 and 20 × 106 viable L. acidophilus organisms and Group C served as a nonsupplemented group. However, they were on medication to lower the cholesterol levels. Fasting blood samples were drawn initially at 0, 30 and after 60 days of supplementation, analyzed for lipid profile which included total cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol. All the recruited subjects completed the study. Comparisons were made on lipid profile at different time periods i.e., 0, 30 and after 60 days of treatment. The supplementation of either 10 × 106 or 20 × 106 viable L. acidophilus showed significant reduction in cholesterol, triglycerides and increase of HDL cholesterol levels. The supplementation of L. acidophilus is found to be beneficial in altering the levels of lipid profile in hypercholesterolemic subjects.
ABSTRACT
In unstable angina (USA) patients, immunological responses contributing to inflammation play a vital role in plaque rupture and thrombosis causing stroke. In the present study an attempt is made to estimate the levels of adenosine deaminase activity, an immunoenzyme marker and C-reactive protein, a marker of inflammation in USA patients. 45 patients presenting USA and 50 age and sex matched healthy controls were included in the study. Serum ADA activity was measured spectrophotometrically at 630nm and serum C-reactive protein was detected using Avitex CRP kit, which is a rapid latex agglutination test. The Mean ADA levels were 41.15 ± 11.04 in patients and 20.71±5.63 in controls and 66.6% of patients and none of the controls were positive to CRP. The present study observed the importance of ADA as a serum marker in addition to CRP for assessing the immune response in USA patients.